{ "method": "MOFAcell-style multicellular + proteome factor analysis (mofapy2 0.7.4)", "n_samples": 8, "groups": { "PE": [ "C1", "C2", "C3", "C5" ], "Control": [ "Z2", "Z3", "Z4", "Z5" ] }, "views": { "SCT": [ 8, 1500 ], "EVT": [ 8, 1500 ], "VCT": [ 8, 1500 ], "Hofbauer": [ 8, 1500 ], "Endothelial": [ 8, 1500 ], "Fibroblast": [ 8, 1500 ], "Proteome": [ 8, 1500 ] }, "n_factors_active": 5, "small_n_floor": "n=4v4 -> min two-sided MWU p = 2/C(8,4) = 0.0286; factors are exploratory", "factor_group_association": [ { "factor": 2, "mwu_p": 0.1143, "perm_p": 0.0857, "abs_mean_diff": 0.557, "max_view_r2": null }, { "factor": 3, "mwu_p": 0.4857, "perm_p": 0.3714, "abs_mean_diff": 0.328, "max_view_r2": null }, { "factor": 4, "mwu_p": 0.3429, "perm_p": 0.5429, "abs_mean_diff": 0.091, "max_view_r2": null }, { "factor": 1, "mwu_p": 0.6857, "perm_p": 0.7429, "abs_mean_diff": 0.692, "max_view_r2": null }, { "factor": 5, "mwu_p": 0.6857, "perm_p": 0.9429, "abs_mean_diff": 0.073, "max_view_r2": null } 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"GBP5", "HLA-G" ], "mean_pctile": 56.5, "signed_w": { "CXCL9": 0.75, "CXCL11": 0.42, "GBP5": 0.582, "HLA-G": 0.969 } }, "Endothelial": { "genes_present": [ "CXCL9", "CXCL10", "GBP5", "IDO1", "HLA-G" ], "mean_pctile": 67.0, "signed_w": { "CXCL9": 0.527, "CXCL10": 0.668, "GBP5": 0.503, "IDO1": 0.216, "HLA-G": 0.439 } }, "Fibroblast": { "genes_present": [ "CXCL9", "CXCL10", "HLA-G", "CD74" ], "mean_pctile": 45.0, "signed_w": { "CXCL9": 0.107, "CXCL10": 0.539, "HLA-G": 1.359, "CD74": 1.153 } }, "Proteome": { "genes_present": [ "CD74" ], "mean_pctile": 97.1, "signed_w": { "CD74": 1.122 } } } }, "top_loadings_best_factor": { "SCT": { "top_pos": [ { "g": "EGFR-AS1", "w": 2.144 }, { "g": "SCGB2B2", "w": 2.066 }, { "g": "CENPJ", "w": 1.964 }, { "g": "SLC44A5", "w": 1.924 }, { "g": "CNTLN", "w": 1.904 }, { "g": "LARS2", "w": 1.881 }, { "g": "PLEKHM3", "w": 1.874 }, { "g": "RMDN2", "w": 1.872 }, { "g": "ECSIT", "w": 1.863 }, { "g": "NSMCE4A", "w": 1.827 }, { "g": "AC040970.1", "w": 1.826 }, { 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